The central image depicts currently used strategies for clinical targeting of TGF-β. Below are methods applicable from preclinical screening to clinical practice, including using humanized mouse ...

Rheumatoid arthritis is a chronic autoimmune disease that affects millions of people worldwide. This disease prompts the ...

Pulmonary fibrosis is a progressive interstitial lung disease characterized by excessive extracellular matrix deposition, ...

Antimicrobial resistance (AMR) poses a major global health challenge by compromising the effectiveness of current therapies for infectious diseases. While ...

Drugs that block enzymes called tyrosine kinases are among the most effective targeted therapies for cancer. However, they ...

Glioma remains one of the deadliest brain cancers, characterized by aggressive growth and limited treatment options. In a new study, researchers from Ningxia Medical University uncovered that choline ...

A tissue section from a mouse model of lung metastasis showing cancer cells (green) that have attracted and activated fibroblasts (red) to support the growth of a metastatic tumor. Image: Massagué Lab ...

Gut microbiome changes may drive age-related memory loss via inflammation and disrupted brain signaling, but interventions in mice show this process can be reversed.