Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known ...

Among the explanations offered for tau’s detrimental effects on neurons in Alzheimer disease is that elevations in tau levels, and/or changes in its cellular distribution, disrupt microtubule function ...

RNA granules, sites for the storage, transport, and regulation of RNA molecules within cells, are transported along axons and then translated locally, far from the cell body. Recent studies suggest ...

The fate of neurons is to be spread thin. Their axons and outlying synapses depend on a constant flow of materials to and from the cell body, making efficient transport a survival skill. Two papers ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

Carnegie Mellon University's Jessica Zhang and Angran Li have developed a new way to model material transport regulation in neurons, focusing on the "traffic jams" that occur in these neural pathways.

Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear.

Huntington's disease is a genetic neurodegenerative disorder caused by mutations in the protein huntingtin and characterized by involuntary dance-like movements, severe behavioural changes and ...