The authors found that Csk (a tyrosine kinase that attenuates B cell receptor signaling) is required for germinal center maintenance and efficient antibody maturation. Osaka, Japan – The immune system ...

New study demonstrates how high-affinity B cells 'bank' their best traits instead of rolling the dice and risking deleterious mutations, with implications for better vaccine design. A vaccine's ...

The development of therapeutic antibodies is a trajectory that moves from identification to optimization. While initial screening campaigns often yield binders with reasonable specificity, early-stage ...