该研究成功从人类肠道噬菌体中，发现了一大批能够抑制II型CRISPR系统的Acr，并揭示了一类全新的、结构高度相似却机制多样的抗CRISPR蛋白家族—GutAcraca 噬菌体编码不同的抗CRISPR (Acr)蛋白来对抗细菌CRISPR-Cas系统 ...

A novel CRISPR defense mechanism, unlike known nucleases, specifically destroys transfer ribonucleic acids (tRNA) that are vital for protein production to shut down infected cells. (Nanowerk News) ...

(Nanowerk News) The CRISPR-Cas gene scissors offer a wide range of potential applications, from the treatment of genetic diseases to antiviral therapies and diagnostics. However, to safely harness ...

In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally ...

Scientists have discovered a new CRISPR mechanism with precise activity, expanding the potential applications of the existing CRISPR toolbox. The CRISPR ‘gene scissors’ have become an important basis ...

Discover how CRISPR genome editing is revolutionizing medicine. Learn the science of Cas9, current clinical trials, and the ...

Bacteria and their viruses, known as phages, are locked in an age-old arms race. To defend against phage attacks, bacteria have evolved sophisticated mechanisms to recognize and counteract invading ...

The cryogenic electron microscope structure of the A4p-activated (green) CalpL protein filament (violet) from Candidatus Cloacimonas acidaminovorans (PDB ID: 9EYJ). CRISPR-Cas systems help to protect ...

In nature, the best-known CRISPR system, CRISPR-Cas9, cuts any RNA or DNA it recognizes as foreign, and thereby protects bacteria from viral attacks. Another CRISPR system, one that is relatively ...

Researchers identified hundreds of anti-CRISPR proteins in human gut phages, including a new dual-function family that blocks ...