Chimeric antigen receptor T-cell therapy—CAR T for short—has been a major advance in treating blood cancers like leukemia and ...

Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a single ...

Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...

A technique that transforms immune cells into cancer-seeking bloodhounds may overcome a roadblock that has hampered ...

A new approach engineers immune cells to recognize byproducts of cancer cells to trigger migration toward the tumor.

UCLA and Stanford Medicine researchers, in collaboration with scientists from the University of Utah and Columbia University, ...

The current path to CAR-T cell therapy is, by any measure, a logistical ordeal. A patient’s immune cells must be drawn out of ...

Signals in our brain are not always processed in the same way: Certain receptors modulate these mechanisms, influencing our mood, perception, and behavior in various ways. One of these is the 5-HT2A ...

Gastrointestinal (GI) cancers remain a major global health burden, accounting for substantial cancer-related morbidity and mortality worldwide. Cell-free ...