A new study reveals that reprogramming specialized cells to become different types of cells, a key process in regenerative medicine, faces a major hurdle. The challenge lies in the DNA methylation ...

When a neuron ages, it loses synaptic connections with other neurons, it is less able to transmit nerve impulses, and its metabolism is also altered. This process of neuronal aging—inevitable with the ...

A new study has shed light on the challenges of converting one type of specialized cell into another, a process critical for advances in regenerative medicine. Despite recent progress in the field, a ...

Life Biosciences has received FDA clearance to begin a first-in-human Phase 1 clinical trial of ER-100, a gene therapy ...

Aging, at its most fundamental level, is a molecular process. Chemical marks on the genome shift and lose fidelity over time, ...

A mature cell of one type can be turned into a mature cell of another type without the cell having to pass through an earlier stage of development. This is called direct reprogramming, a reliable but ...

Induced pluripotent stem cells (iPSCs) are derived from adult cells, such as skin or blood cells, which have been “reprogrammed” back to a stem-cell-like state. This transformation grants them the ...

Promising mouse studies and billions of dollars in funding are stoking excitement. But we’ve been here before.

AbstractNon apoptotic cell death programs particularly ferroptosis and cuproptosis are transforming how we understand cancer ...