精子生成中中心体的超微结构动态与POC5内 scaffold的功能研究。使用超分辨率扩展显微技术(U-ExM)揭示小鼠精子细胞中心体发生几何构型转换、远端尖部蛋白(如centrin和SFI1)选择性丢失,并发现DC的POC5-内 scaffold增强对维持结构完整性及鞭毛组装至关重要。
Abnormal centrosome numbers are detected in virtually all cancers. The molecular mechanisms that underlie centrosome amplification, however, are poorly characterized. Based on the model that each ...
Centrins are evolutionarily conserved calcium-binding proteins, which are ubiquitously found in eukaryotes and participate in a number of cellular processes, including centriole and basal body ...