Chloride channels and antiport mechanisms are pivotal for maintaining cellular ion homeostasis and regulating physiological processes such as muscle contraction, epithelial fluid transport and ...

Chloride channels, particularly those of the CLC family, are vital for cellular homeostasis by facilitating the exchange of chloride ions and protons across membranes. These transport proteins govern ...

The field of neurotrauma and epilepsy research has increasingly highlighted the pivotal influence of ion channels in the transition from traumatic brain ...

"Why did nature come up with such a structural plan?" ask Rockefeller University professor Roderick MacKinnon and colleagues in their Jan. 17 Nature cover article describing the three-dimensional ...

Efforts to understand the most common cause of vision loss in millions of elderly people have led to the discovery of an entirely new family of chloride ion channels that are found in animals from ...

Maintenance of cardiac rhythm and pain sensation require the flow of ions across the membranes of all cells. Ion channels, which facilitate this movement, are protein assemblies that penetrate the ...

BioRxiv (2023) PubMed PMID: 37546940; PubMed Central PMCID: PMC10402079. The mammalian innate immune system uses cyclic GMP–AMP synthase (cGAS) to synthesize the cyclic dinucleotide 2′,3′-cGAMP during ...

Scientists identified a previously unknown chloride ion channel, which they named alkaliphile (Alka), as a taste receptor for alkaline pH. The sense of taste is among the first to come into contact ...

Credit: Shutterstock. NMD670 is a first-in-class small molecule inhibitor of the skeletal muscle specific chloride ion channel. The Food and Drug Administration (FDA) has granted Orphan Drug ...

Neuromuscular disease specialist NMD Pharma A/S has been given U.S. FDA approval for a phase IIb trial of NMD-670, after demonstrating proof of mechanism for the orally-available chloride ion ...

NMD Pharma Publishes Comprehensive Data Package for NMD670 in Science Translational Medicine ClC-1 is a chloride ion channel specifically expressed in skeletal muscle cells that normally dampens ...

(Nanowerk Spotlight) Biological brains compute using ions, not electrons. Every signal between neurons depends on charged atoms passing through protein channels embedded in cell membranes, a system ...