在人类基因组中，98%是“不编码蛋白”的DNA，却可能决定疾病的发生。旗下DeepMind公司开发的人工智能模型AlphaGenome登上Nature封面，尝试直接“读懂”这些被忽视的非编码区域，为罕见病诊断提供新的线索。

Deep-learning model decodes the regulatory effects of DNA changes ...

Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. St. Jude Children's Research Hospital scientists have identified specific DNA variants in the ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...

For decades, biologists have known that the instructions for life are written in DNA, yet the vast majority of those letters seemed to sit in the dark, doing little that was obvious. Now a new ...

A tiny percentage of our DNA—around 2%—contains 20,000-odd genes. The remaining 98%—long known as the non-coding genome, or so-called 'junk' DNA—includes many of the "switches" that control when and ...

Life runs on instructions you never see. Every cell reads DNA, turns that message into RNA, and then builds proteins that ...

In mammals, only 3% of the genome consists of coding genes which, when transcribed into proteins, ensure the biological functions of the organism and the in-utero development of future individuals.

In a recent preprint* uploaded to the bioRxiv server, researchers developed and trained a foundational model to predict tissue-specific RNA expression, splicing, RNA binding protein specificity, and ...

Researchers have revealed that so-called ‘junk DNA’ contains powerful switches that help control brain cells linked to Alzheimer’s disease. When people picture DNA, they often imagine a set of genes ...