结缔组织病（Connective tissue disease）的特征在于 B 细胞的活化以及特定自身抗体的存在。自身抗体不仅是个体疾病的标志，还能激活与疾病相关的分子通路。B 细胞通过释放炎性细胞因子、抗原呈递以及促进巨噬细胞活化来驱动自身免疫性疾病的发病机制。抗合成酶综合征 （ASyS）和系统性硬化症（SSc）是两种由自身免疫介导的结缔组织病，对新型疗法有着特别高的医疗需求。

Experts highlight the role of primary care in identifying joint hypermobility syndrome and distinguishing it from connective tissue disorders.

The U.S. Social Security Administration has requested the National Academies of Sciences, Engineering, and Medicine establish an ad hoc committee to review certain heritable conditions related to ...

This activity was supported by Contract/Task Order No. 28321318D00060015/00003 between the National Academy of Sciences and the U.S. Social Security Administration. Any opinions, findings, conclusions ...

Aortic dissection during pregnancy represents a critical clinical challenge, particularly among women with pre‐existing connective tissue disorders such as Marfan syndrome. The physiological changes ...

Collaborative research efforts are geared to improving disease that affects connective tissues via innovative drug delivery systems. Researchers at the University of Delaware (UD) have devised tiny ...

Nearly 1 in 3 patients with connective tissue disease-associated interstitial lung disease will develop progressive pulmonary fibrosis.

University of Delaware Professor Kristi Kiick is leading collaborative research to create new drug delivery systems with the potential to improve treatment for diseases that affect connective tissues, ...

Focusing on CTD-PAH, key opinion leaders discuss how the disease can be identified and relevant impact on quality of life. Transcript: Charles D. Burger, MD: When examining patients in the ...

A research team has devised tiny cargo-carrying systems many times smaller than a human hair, made from molecules called peptides that help provide structure for cells and tissues. The team has ...