Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

A new study in fruit flies describes how an animal's gut reacts differently to beneficial microbes versus harmful pathogens. A pathway known for repairing damaged genetic material, called the ...

An elegant collaboration between researchers in the UK's two core-funded Medical Research Council Research Institutes, the Laboratory of Medical Sciences (LMS) in London and the Laboratory of ...

Outcomes of nephrectomy in patients with pathologic complete response to immune checkpoint inhibitor therapy for renal cell carcinoma: A multicenter study. Sarcomatoid versus rhabdoid ...

New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

An important DNA modification is methylation, or the addition of a methyl group to the 5th carbon of cytosine. This forms 5-methylcytosine (5mC), typically associated with repression of gene ...

Scientists discover ALS protein that links DNA repair to cancer and dementia: Study ...

A protein long studied for its role in amyotrophic lateral sclerosis and frontotemporal dementia now appears to serve a ...

Daegu Gyeongbuk Institute of Science and Technology (DGIST; President Kunwoo Lee) announced that a research team led by Professor Younghoon Kee from the Department of New Biology has successfully ...