Determining and evaluating the affinity of small molecule binding to a therapeutic target is a major component of drug discovery and lead optimization. In a technical note entitled “Label-free ...

Proteins are made up of amino acid residues which are bound together by peptide bonds between the amino nitrogen (N) and the carboxyl group. Just 21 distinct amino acids exist, but they can bind ...

Colloidal stability is calculated by balancing repulsive and attractive intermolecular interactions among protein molecules to sustain the native folded state. Less intermolecular interaction reduces ...