2月19日，中国科学技术大学生命科学与医学部张凯课题组在《自然》在线发表题为“Roles of microtubules and LIS1 in dynein transport machinery assembly”的研究论文。该研究系统性地揭示了微管与LIS1介导的胞质动力蛋白-1（dynein）运输系统的组装与启动的新机制，这与领域 ...

北京时间2026年2月19日，中国科学技术大学生命科学与医学部张凯课题组在Nature期刊在线发表了题为“Roles of microtubules and LIS1 in dynein transport machinery assembly”的研究论文。 该研究系统性地揭示了微管与LIS1介导的胞质动力蛋白-1（dynein）运输系统的组装与启动的新 ...

该研究系统性地揭示了微管与LIS1介导的胞质动力蛋白-1（dynein）运输系统的组装与启动的新机制，这与领域过去十多年盛行的经典模型显著不同。 细胞质动力蛋白-1是一种基于微管(MT)的马达蛋白，需要动力蛋白和卷曲螺旋接头来形成进行性动力蛋白-动力蛋白 ...

Cytoplasmic dynein is a microtubule motor involved in cargo transport, nuclear migration and cell division. Despite structural conservation of the dynein motor domain from yeast to higher eukaryotes, ...

本研究针对大细胞器（1-5 μm吞噬体）在逆行运输中所需高集体力的产生机制这一关键问题，通过力测量、动力蛋白（dynein）定量和理论建模，首次揭示吞噬体体积与运输力（10-160 pN）的正相关关系，发现最大吞噬体可募集250个dynein并通过微管重分布机制协同产生 ...

来自国际顶尖团队的研究人员通过系统性冷冻电镜技术，揭示了人类全长动力蛋白1(Dynein 1)在微管结合状态下的机械化学循环机制。该研究捕获了8种状态、40余个高分辨率结构，提出了"后门磷酸盐释放"模型，阐明了微管结合增强ATP酶活性的双向通讯机制，并修正 ...

A team led by scientists at The Scripps Research Institute (TSRI) has determined the basic structural organization of a molecular motor that hauls cargoes and performs other critical functions within ...

Nearly 50 years after the discovery of the walking molecular motor dynein, researchers have finally solved the first X-ray crystal structure of its massive motor domain. The milestone will permit ...

Intracellular protein aggregation is a common theme in neurodegenerative disease. The formation of aggregates is blamed on protein overproduction, a failure of clearance, or both. Score one for the ...

Our cells rely on microscopic highways and specialized protein vehicles to move everything—from positioning organelles to carting protein instructions to disposing of cellular garbage. These highways ...

Researchers have uncovered the mechanism by which a protein facilitates the spread of breast cancer cells from the primary tumor into healthy tissue. The discovery not only improves our understanding ...