Did you know that genes can mask and alter the effects of other genes? Could this process, called epistasis, be a key to understanding complex conditions like Alzheimer’s disease and diabetes?

Most pathway and gene-set enrichment methods prioritize genes by their main effect and do not account for variation due to interactions in the pathway. A portion of the presumed missing heritability ...

We apply new analytical methods to understand the consequences of population bottlenecks for expected additive genetic variance. We analyze essentially all models for multilocus epistasis that have ...

Abstract: Early‐generation hybrid fitness is difficult to interpret because heterosis can obscure the effects of hybrid breakdown. We used controlled reciprocal crosses and common garden experiments ...

Jim Manzi has a long post up on epistasis, that is, gene-gene interactions: We could call this process of competing algorithms struggling to find the best solution as fast as possible "meta-evolution" ...

Statistical method developed may be used to identify sites of importance for viral adaptation. A group of investigators report developing a new phylogenetic method for detecting epistasis. They ...

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, has undergone genomic mutations, which have led to the ...

Large‑scale protein evolution model reveals that common ancestry, not selection or epistasis, is the dominant force limiting ...

Why evolutionary genetics does not always add up / Edmund D. Brodie III -- Beyond the average : the evolutionary importance of gene interactions and variability of epistatic effects / Patrick C.

A recent article in the journal Chaos examines the possibility of using epistasis to predict the outcome of the evolutionary processes, especially when the evolving units are pathogens such as viruses ...