Researchers demonstrate that combinations of antiviral drugs inhibiting both polymerase and exonuclease reduce SARS-CoV-2 replication 10 times more than polymerase inhibitors alone. Researchers from ...

When an SSB appears, polymerase epsilon approaches the nick before retracing its steps thanks to its exonuclease, allowing fork reversal to take place. The nick is repaired as an SSB, and replication ...

Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...