Researchers at the Indian Institute of Science and collaborators used cryo-EM to decode the molecular architecture of a transporter protein controlling the movement of gamma-aminobutyric acid (GABA).

Efforts to better understand how immune cells function hold the promise of providing information that might lead to improved clinical treatments. Writing in Nature, Zhang et al. 1 present results that ...

Gamma aminobutyric acid (GABA) is a naturally occurring amino acid that works as a neurotransmitter in your brain. GABA is considered an inhibitory neurotransmitter because it inhibits certain brain ...

One of the smallest protein structures ever determined using cryo-EM, GAT1 is fundamental to GABA neurotransmission and its structural determination is pivotal to developing therapies for a range of ...

Artist’s rendering of GABA transporter 1 (GAT-1) embedded in a neuron’s membrane. Tiagabine (green) blocks GAT-1 from shuttling the neurotransmitter GABA (yellow and red) into the cell from the ...

Using Cryo-EM, a powerful microscopy technique, researchers at IISc and collaborators have decoded the molecular architecture of a transporter protein controlling the movement of a key ...