A new study from the Italian Institute of Technology (IIT), in collaboration with Uppsala University (Sweden) and AstraZeneca, shows how computational chemistry and supercomputers can help scientists ...

Human periportal assembloid, showcasing the three key cell types of the liver: portal fibroblasts (magenta), cholangiocytes (green), and hepatocyte nuclei (blue). All cell borders are delineated in ...

Typically, bone marrow research relies heavily on animal models and oversimplified cell cultures in the laboratory. Now, researchers from the Department of Biomedicine at the University of Basel and ...

Assembloids: A Versatile Platform for Human Tissue Modeling. This schematic illustrates the classification of assembloids based on four key assembly strategies—multi-region, multi-lineage, ...

To create a cervix-on-a-chip, the researchers added cells that line the cervical canal to one channel of a microfluidic device. To an adjacent channel, they introduced cervical fibroblasts that form ...

The purpose of this chapter is to provide general methodological guidelines for the development, instantiation, and validation of models of human behavior. We begin with a section describing the need ...

Support organoid research with scalable human-based systems that enhance reproducibility and accelerate breakthroughs in ...

In April, the FDA announced an ambitious plan to phase out animal testing requirements for monoclonal antibodies and other therapies in an effort to improve drug safety and reduce R&D costs. The goal ...

A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling. Scientists at The University of Texas Health Science Center at San Antonio have created ...

Scientists have produced an organoid model of the human conjunctiva. These organoids mimic the function of the actual human conjunctiva, a tissue involved in tear production. Using their new model, ...