在体外，氨上调肠神经元上电压门控钙通道的表达，驱动Ca2+内流以增强ACh分泌。该研究揭示了一种微生物代偿机制，该机制对肠道中ACh水平的波动做出反应，并为肠道运动障碍提供了微生物靶点。

Chronic Intestinal Pseudo-Obstruction (CIPO) and related gastrointestinal motility disorders constitute a group of rare but debilitating conditions that mimic mechanical obstruction despite the ...

Ferulic acid suppresses ileal smooth muscle contraction by inhibiting calcium ion influx through voltage-dependent calcium channels. This action may help prevent or treat excessive intestinal motility ...

Together, these findings suggest that ferulic acid can act as a natural regulator of intestinal motility. By reducing excessive smooth muscle activity, the compound could potentially help calm ...

Maternal health and other events occurring during pregnancy determine the health outcomes in offspring. Pre-natal infections are a major risk factor contributing to compromised intestinal barrier ...

Engineers have developed an ingestible sensor whose location can be monitored as it moves through the digestive tract, an advance that could help doctors more easily diagnose gastrointestinal motility ...

Scientists show that the receptor PIEZO2 in sensory neurons controls gut motility and transit time, which are important for digestion and nutrient absorption. Gastrointestinal and digestive issues ...

After every meal, the intestines perform an action called peristalsis - moving food through their hollow interiors with coordinated contractions and relaxations of the smooth muscle. For more than a ...

A multi-institutional group of researchers led by the Hubrecht Institute and Roche's Institute of Human Biology has developed strategies to identify regulators of intestinal hormone secretion. In ...

Anxiety affects gut motility, causing diarrhea or constipation, and can exacerbate conditions like IBS by altering intestinal contractions. Stress increases intestinal inflammation by weakening the ...

A mutation previously linked to skin disorders like psoriasis may also play a surprising role in gut health, according to new research published by scientists at VIB-UGent and colleagues from UGent, ...