Intracellular peptides, generated predominantly via the ubiquitin–proteasome system, have emerged as critical modulators of cell signalling. These peptides play multifaceted roles, ranging from ...

In a recently published review, a research team led by MedUni Vienna has highlighted a promising new approach to drug discovery. The focus is on the targeted modulation of certain intracellular ...

Skin, our largest organ, acts as a protective barrier against pathogens that try to invade our bodies while constantly ...

A multinational research team has revealed how a tryptophan-rich allosteric communication network regulates receptor dynamics ...

Background: Wnt signaling affects fundamental development pathways by regulating cell proliferation and differentiation. Aberrant activation of Wnt/ß-catenin signaling promotes the development of ...

Researchers report a drug discovery strategy using tailor-made cyclic peptides to target β-arrestins, key regulators of ...

Targeted modulation of certain intracellular signaling proteins could represent an exciting new approach to drug development.

The GPCRact AI model goes beyond AlphaFold3 by predicting whether drugs functionally activate G-protein-coupled receptors ...

A synthetic tripeptide inspired by snake venom is opening new investigative routes into cellular signalling and structural ...