首次系统阐明了哺乳动物Ste20样激酶1（Mammalian Ste20-like kinase 1，MST1）在AD神经炎症中的调控作用及分子机制，为AD的免疫干预治疗提供了全新靶点与研究方向。 阿尔茨海默病（Alzheimer’s disease ...

If approved, Joenja® (leniolisib) would become the first approved treatment in the European Union for activated phosphoinositide 3-kinase delta ...

The team classified more than 300,000 bacterial serine-threonine kinase sequences from the National Center for Biotechnology Information's reference sequence (RefSeq) of nonredundant protein databases ...

Few effective treatments exist to treat neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). 1 Existing treatments focus on ...

The oral molecular glue degrader aims to overcome resistance to standard ALK tyrosine kinase inhibitor therapies.

Protein kinase inhibitors represent a major advance in cancer treatment due to their ability to target the specific kinases involved in tumor growth and survival. More than 80 small-molecule protein ...