The spindle assembly checkpoint arrests mitotic progression until each kinetochore secures a stable attachment to the spindle. Despite fluctuating noise, this checkpoint remains robust and remarkably ...

We have studied cytoskeletal architectures of isolated mitotic apparatus from sea urchin eggs using quick-freeze, deep-etch electron microscopy. This method revealed the existence of an extensive ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

Zachary Gergely, Ammon Crapo, Loren Hough, J. Richard McIntosh, and Meredith D. Betterton (2016). Molecular Biology of the Cell27, 3490. arXiv DOI: 1604.08134. DOI: 10.1091/mbc.E15-07-0505. Download.

A research team led by Prof. YAO Xuebiao, LIU Xing and ZANG Jianye from University of Science and Technology of China (USTC) revealed how crotonylation of EB1 helped orientate spindle in mitosis. The ...

For a new plant to grow from a seed, cells need to divide numerous times. Daughter cells can each take on different tasks and sometimes vary in size. How plants determine the plane of cell division in ...

For a new plant to grow from a seed, cells need to divide numerous times. Daughter cells can each take on different tasks and sometimes vary in size. How plants determine the plane of cell division in ...

Scientists have gained new insight into the formation of the spindle, which is the molecular machine that divides up genetic material prior to cell division. Their work focuses on the motor protein, ...

Mitosis is the process by which the genetic information encoded on chromosomes is equally distributed to two daughter cells, a fundamental feature of all life on earth. Scientists now examine how ...

Microtubules, the dynamic filaments that form the cell's internal scaffolding, have long been viewed as mere passive ...

Spindle microtubules are yellow, with actin cytoskeletal filaments blue in this mitotic spindle. There is fresh recognition that cells' ability to build the structures that carry out cell division: ...