Despite progress in defining functional elements of noncoding DNA, it is still not fully understood. UCLA researchers, using an experiment that elucidated the function of tens of thousands of ...

Oestrogen-induced DNA damage drives genomic instability in BRCA1 mutation cells, with dietary compounds showing protective potential.

Jian Carrot-Zhang is in the Computational Oncology Program, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York City, New York 10065, USA, and in the ...

New research has found that oestrogen-induced DNA damage in individuals carrying BRCA1 mutations may play a crucial role in the initiation of cancer, while also pointing to a potential dietary ...

Researchers have refined a powerful DNA sequencing tool that can uncover hidden mutations that occur naturally in our bodies as we age. In the largest study to date, they have used the tool to provide ...

Geneticists looking inside the nuclear genome for mutations that contribute to disease have long relied on a principal known as constraint modeling, which allows researchers to assess the degree of ...

Mitochondria act as energy factories in cells and have their own, separate DNA. Mutations to mitochondrial DNA (mtDNA) have been observed in cancer, but it has been unclear how these changes might ...

Cancer associated macrophages in blood correlates with poor outcomes in patients with clinically resectable disease in gastrointestinal cancers. This is an ASCO Meeting Abstract from the 2024 ASCO ...

A new study from deCODE genetics uses pedigrees and sequence data from 64,806 Icelanders to shed light on the rate and nature of mutations in mitochondrial DNA (mtDNA) and the peculiar dynamics of its ...

Characteristics of Clonal Hematopoiesis (CH) Mutations - a) We identified somatic mutations in known clonal hematopoiesis of indeterminate potential (CHIP) driver genes using peripheral blood ...

Mice pups conceived with in vitro fertilization (IVF) in the lab have slightly increased rates of DNA errors, or mutations, compared to pups conceived naturally, a new study on artificial reproductive ...