该亚型在HCC中高表达，并与患者不良预后相关，但其自身并不编码可检测的蛋白质产物。SLCO2B1-isoN的5'末端茎环结构使其丧失翻译能力，从而转变为一种非编码RNA。SLCO2B1-isoN这一非编码亚型通过促进新生蛋白质生物合成，稳定了脆性X信 ...
Researchers identified biallelic variants in RNU2-2 as the cause of a recessive neurodevelopmental disorder marked by ...
Like tiny superheroes, small, naturally occurring segments of RNA can block multiple molecular paths that cancer cells use to ...
Long non-coding RNAs exist in the so-called "Wild West" (99%) of the human genome that is currently understudied. Not only does this finding have treatment implications for patients with ...
Terc-53 functions as a molecular scaffold bringing together Hmmr and Trim25, accelerating Hmmr’s ubiquitination-mediated degradation, which consequently leads to neuroinflammation and cognition ...
In a recent study, researchers at the Texas A&M University Health Science Center (Texas A&M Health) identify a novel RNA molecule that plays a crucial role in preserving the integrity of a key ...
What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases. Until now, the genetic basis ...
A research team led by scientists at Columbia’s Zuckerman Institute used techniques including single cell genomics, to describe a previously undetected RNA-mediated mechanism in mice that could ...
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