The dehydrogenase complexes serve as pivotal regulators in cellular metabolism, orchestrating key oxidative reactions within the tricarboxylic acid (TCA) cycle and beyond. These multi‐enzyme ...
The isocitrate dehydrogenase (IDH) enzyme family catalyzes the oxidative decarboxylation of isocitrate to produce α-ketoglutarate (α-KG). IDH1 and IDH2 mutants use the latter to generate the oncogenic ...
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