BackgroundPhytochemicals—bioactive molecules derived from plants—have a long history in traditional medicine and have already given rise to several modern ...

A breakthrough discovery reveals how the SLC45A4 gene fine-tunes polyamine transport in sensory neurons, reshaping our understanding of pain and opening new paths for targeted therapies. Study: ...

The thermal grill illusion (TGI) is a striking phenomenon in which the simultaneous application of interlaced warm and cool stimuli to the skin produces paradoxical sensations of burning heat and pain ...

Tsukuba, Japan—Pain perception can vary greatly. Sometimes, we feel pain more intensely than expected due to an injury or physical ailment but may feel less intense pain at other similar instances.

Pain perception in affected individuals is more strongly influenced by learned fear than in healthy individuals. Changes along the gut-brain axis related to chronic inflammation may explain this. Many ...

Nearly half of the patients with rheumatoid arthritis (RA) in sustained clinical and ultrasound remission still report unacceptable pain, with women experiencing higher pain levels than men. Patient ...

Pain has a protective role. A primary role of acute pain is to protect us from further harm. For example, a painful blister on your foot can motivate you to stop walking or to wear more comfortable ...

A new study has found that the brain system enabling us to inhibit our own pain changes with age, and that gender-based differences in those changes may lead females to be more sensitive to moderate ...

Researchers used visual threat manipulation in the virtual reality environment and thermal stimulation to investigate how the brain perceives pain. They found that the brain perceives pain more ...

Pain perception to minor physical stimuli prior to surgery could be related to subsequent pain ratings after surgery, according to a literature review published in the Feb. 2011 issue of ...

Swearing is not an uncommon response to pain. But does it actually reduce pain perception or pain tolerance? Yes, according to recent research, by Hostetter and colleagues, published in the April 2024 ...