该研究提出，细胞培养基的代谢组成与生理环境之间存在差异，可能是导致 LNPs 吸收差异的原因。 脂质纳米颗粒（LNPs）是用于治疗性 mRNA 递送的强大平台；然而，在传统细胞培养条件下开发的优化策略并不总是能预测体内 LNPs 的效果。

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