Alternative polyadenylation is a vital gene function regulatory mechanism, occurring in more than 60% of human genes. The process is required for the synthesis of diverse mRNAs and proteins from a ...

A team led by Dr. Eddie Imada, assistant professor of research in pathology and laboratory medicine, has been awarded a three-year, $1.5 million United States Department of Defense grant for research ...

Recent research on Arabidopsis thaliana flowering may sow the seed of new connections between plant and human reproduction. Gordon Simpson and Caroline Dean at the John Innes Center in Norwich, UK, ...

Researchers with an interest in unraveling gene regulation in human health and disease are expanding their horizons by closely looking at alternative polyadenylation (APA), an under-charted mechanism ...

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

Meet PolyA-miner, a new computational tool that enables scientists to evaluate the contribution of alternative polyadenylation to gene regulation in health and disease. Researchers with an interest in ...

NUDT21 regulates fibroblast senescence and is significantly decreased in aged and fibrotic lungs, impacting IPF progression. Alternative polyadenylation (APA) and NUDT21 downregulation enhance STAT3 ...