A new study shows p62-mediated Mallory-Denk body formation is an adaptive, protective response to alcohol-induced liver ...

Protein-based therapeutics have transformed treatments for numerous diseases, yet their production remains highly complex and cost-intensive [1][2],[3][4]. Downstream processing (DSP), including ...

Protein-based medicines are increasingly prevalent as a crucial category of contemporary therapeutics. The presence of ...

Targeted protein degradation (TPD) is a rapidly advancing field with high potential in addressing proteotoxic stress and managing disease progression. TPD has generated a lot of interest in the last ...

Researchers have developed a 'self-driving' microscope that can predict the onset of misfolded protein aggregation - a hallmark of neurodegenerative disease - as well as analyze the biomechanical ...

A new study from scientists at VIB-KU Leuven Center for Brain & Disease and elsewhere reveals the role of an RNA binding protein called Fused in Sarcoma (FUS) in the development of frontotemporal ...

Protein misfolding and aggregation are key features observed in numerous neurodegenerative conditions, such as Alzheimer's and Parkinson's disease. The oligomers formed during the aggregation process ...

Durable analytical instruments expedite the study of misfolded proteins linked to neurodegenerative diseases. To overcome these limitations, scientists developed the real-time quaking-induced ...

Neurodegenerative diseases, such as Parkinson’s or Alzheimer’s, are associated with the deposition of protein aggregates in the brain. These aggregates accumulate when the cellular waste removal ...

Patients with Huntington's disease have a genetic mutation that triggers proteins to misfold and clump together in the brain. These clumps interfere with cell function and eventually lead to cell ...

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington’s, Alzheimer’s and Parkinson’s. But to the human eye, proteins that are ...