A new study shows p62-mediated Mallory-Denk body formation is an adaptive, protective response to alcohol-induced liver ...

Protein-based therapeutics have transformed treatments for numerous diseases, yet their production remains highly complex and cost-intensive [1][2],[3][4]. Downstream processing (DSP), including ...

Alcohol-associated liver disease (ALD) remains a leading cause of cirrhosis and liver-related mortality worldwide, with few effective therapies. In alcohol-associated hepatitis (AH), hepatocytes ...

Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are characterized by the abnormal aggregation of pathological proteins ...

Protein misfolding and aggregation are key features observed in numerous neurodegenerative conditions, such as Alzheimer's and Parkinson's disease. The oligomers formed during the aggregation process ...

A new study from scientists at VIB-KU Leuven Center for Brain & Disease and elsewhere reveals the role of an RNA binding protein called Fused in Sarcoma (FUS) in the development of frontotemporal ...

Scientists at the Utrecht University in the Netherlands say they have identified a new way in which the toxic protein aggregates associated with Huntington’s disease may damage nerve cells and cause ...

Durable analytical instruments expedite the study of misfolded proteins linked to neurodegenerative diseases. To overcome these limitations, scientists developed the real-time quaking-induced ...

Researchers have developed a 'self-driving' microscope that can predict the onset of misfolded protein aggregation - a hallmark of neurodegenerative disease - as well as analyze the biomechanical ...

Can mirror proteins cure Alzheimer's? Scientists used "right-handed" amino acids to trap amyloid-beta proteins. This breakthrough in molecular recognition offers a new way to target "undruggable" ...

Researchers at the Institute for Bioengineering of Catalonia (IBEC) have produced a mutational map showing how mutations in ...

Understanding how proteins interact with their own mirror images enabled a Kobe University research team to design a small ...