Proteins are the end products of the decoding process that starts with the information in cellular DNA. As workhorses of the cell, proteins compose structural and motor elements in the cell, and they ...

In the wee hours of an October morning, David Baker, a protein biologist at the University of Washington (UW), received the most-awaited phone call in a scientist’s career. Halfway around the world, ...

When a protein folds, its string of amino acids wiggles and jiggles through countless conformations before it forms a fully folded, functional protein. This rapid and complex process is hard to ...

This review provides an overview of traditional and modern methods for protein structure prediction and their characteristics and introduces the groundbreaking network features of the AlphaFold family ...

Researchers at Pacific Northwest National Laboratory used artificial intelligence to analyze protein nanoribbons, pointing to ...

The function of a protein is usually determined by the ligands that it binds to. The 3D structure of the binding groove or pocket can be compared to other proteins and similar residues used to make ...

The prediction of protein structure with the use of artificial intelligence and machine learning (AI–ML) is poised to transform how and when three-dimensional (3D) biostructure information is used in ...

The “ChatGPT moment” for biology proceeds to unfold as protein language models, or machine learning tools trained on large databases of protein sequences, work to decode the language of life with the ...

Doubly stapled α-helix consisting only of achiral amino acids. Its one-handed form can be isolated because the interconversion between the right- and left-handed forms is almost completely suppressed.

Using a tool to solve a protein's structure, for most researchers in the world of structural biology and computational chemistry, is not unlike using the Rosetta Stone to unlock the secrets of ancient ...

Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which is important in the detection of various stimuli. Here, researchers found that the protein that regulates ...