Cancer metastasis is a crucial area in cancer research that directly affects patient survival and treatment outcomes. Cancer cells often undergo adaptive metabolic changes during metastasis from in ...

Failure to import pyruvate into the mitochondria of cardiomyocytes results in metabolic maladaptation, cardiac hypertrophy and heart failure, thus underscoring the central role of pyruvate metabolism ...

image: Medical College of Georgia researchers are trying to open a door for a killer that breast cancer cells shut out. Pyruvate is a metabolite in the blood that is lethal to rapidly-multiplying ...

Researchers are trying to open a door for a killer that breast cancer cells shut out. “If we can figure out how to do that, we could have a new therapeutic target for fighting breast cancer,” says Dr.