Receptor tyrosine kinases (RTKs) regulate many critical biological processes such as cell growth, differentiation, and survival through the recruitment of intracellular signaling molecules. The ...

The NF-κB-inducing kinase (NIK), a molecule pivotal for immune system development and function, shows significant yet complex ...

From studies conducted on animals, evidence has emerged that both neutralizing activity and Fc-mediated effector functions of neutralizing antibodies provide some levels of protection against the ...

Plant immunity is largely initiated at the cellular level, with each cell capable of autonomous detection and response, while also coordinating ...

– Data provide insights on the signaling pathways involved with AK006 mast cell inhibition –– AK006 has a distinct mechanism of action that leads to broad inhibitory effects on mast cells – The ...

Two decades ago, Professor Shao-Cong Sun first discovered the non-canonical NF-κB pathway mediated by NF-κB-inducing kinase (NIK). Since then, more ...

Scientists have revealed that direct physical associations between plant immune proteins and fungal molecules are widespread during attempted infection. The authors' findings run counter to current ...

Like animals, plants need to be on a constant lookout to recognize and respond to invasion by microbes. Plant immunity consists of two branches—the initial defense begins with the detection of ...

From the Riddell, Paulovich Labs, Clinical Research Division and Gottardo Lab, Vaccine and Infectious Disease Division. In order to identify why the different costimulatory domains have differing ...

CONVERGE-01: Dosimetry, randomized dose optimization, dose escalation, and efficacy of ac-225 rosopatamab tetraxetan in participants with PSMA-positive castration-resistant prostate cancer. This is an ...