mobocertinib是一种针对EGFR外显子20插入突变的非小细胞肺癌靶向药物，但其合成和储存过程中可能产生杂质影响疗效与安全。本研究开发了一种高效液相色谱法（RP-HPLC）实现 mobocertinib及其6种相关杂质（imp-A-F）的同时分离与定量检测，并通过核磁共振（NMR）和高 ...

High performance liquid chromatography, more commonly known by the acronym HPLC, is a method used to identify substances in a mixture. There are several types of HPLC, such as reversed-phase, ...

Synthetic DNA- and RNA-based oligonucleotides are among many successful biotherapeutic drugs to treat many different kinds of illnesses. They are synthesized in a multistep process. Although coupling ...

Any analytical method must strike a balance between its intrinsic scientific potential its capacity for robustness and reliability, particularly in regulated industries. In the case of HPLC, this ...

This week's highlights feature our ongoing discussions on women in chromatography, an interview on the future of HPLC columns from analytica 2026, and cutting-edge applications of mass spectrometry ...

The term liquid chromatography (LC) refers to a class of physicochemical methods which are used to separate and quantify compounds in a sample. LC is made up of a liquid mobile phase, which carries ...