造血干细胞是维系机体终身血液系统稳态的核心基石，其移植疗法已成为白血病、再生障碍性贫血等恶性及遗传性血液病的有效救治手段。转录因子 Bcl11a 在造血过程中发挥着关键作用，广泛调控 B 细胞、早期 T ...

Targeting organ‑specific gene “switches” can reverse key markers of liver aging in mice, suggesting aging might be slowed one ...

Researchers from the A*STAR Institute of Molecular and Cell Biology (IMCB) have identified Nr1h2, a critical transcription factor essential for early embryo development. Published in Nature ...

A research group has revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease. Crohn's disease is an intractable disorder characterized ...

Transcription factors are a class of proteins that interact with DNA to regulate gene expression. They’re also implicated in many cancers. For years, scientists have considered transcription factors ...

Researchers at Johns Hopkins University and the University of Maryland School of Pharmacy have developed a set of novel, ...

Auckland, New Zealand-based GeneDetect.com has designed ODN decoys to more than 45 common transcription factors, with plans to release more. Each decoy is a double-stranded, synthetic phosphorothioate ...

Research into transcription factors deepen understanding of the 'language' of the genome, offering insights into human development. New research has uncovered more about the complexity of human gene ...

Researchers have found that certain bacteria carry a naturally occurring system, built from repurposed CRISPR components, ...