A new review links three forces shaping osteoarthritis: mechanical stress, integrin signaling, and integrin endocytosis. The ...

Our cells are constantly being pushed, stretched, and compressed without our awareness: a play of invisible forces that influences their behavior. A study published in the journal Lab on a ...

Growing from a single cell into a complex organism with specialized tissues and organs requires a complex and coordinated process. But the mechanical signals that guide tissue and organ ...

Neurons are important, but they are not everything. Indeed, it is "cartilage," in the form of clusters of extracellular matrix molecules called chondroitin sulfates, located in the outside nerve cells ...

In cell and animal models of amyotrophic lateral sclerosis (ALS), the expression of toxic dipeptides in neurons led to changes in the extracellular matrix (ECM) as a protective response. The authors ...

Peptide science has expanded rapidly in recent decades, revealing molecules with intriguing signaling roles that may influence diverse regenerative and organizational processes within an organism.

Hypertrophic scarring affects a large proportion of patients following burns, trauma, or surgery and arises from prolonged fibroblast hyperactivity and excessive extracellular matrix accumulation.

RIT biomedical engineering researchers identify a protein that can reduce fibrosis and slow disease progression.