Preclinical studies show that engineered heart muscle (EHM) can remuscularize damaged heart tissue, but most evidence comes from small-animal studies, which have limited ability to predict outcomes in ...

In a large-animal model study, researchers have found that heart attack recovery is aided by injection of heart muscle cell spheroids derived from human induced pluripotent stem cells, or hiPSCs, that ...

New research from a multi-institutional team, published in Nature Cardiovascular Research, reveals that heart failure and atrial fibrillation share underlying genetic and molecular mechanisms, ...

Cardiovascular disease continues to be the leading cause of death worldwide. But advances in heart-failure therapeutics have stalled, largely due to the difficulty of delivering treatments at the ...

A new gene therapy can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the amount of blood the heart can pump and dramatically improves ...

Injecting infarcted pig hearts with specially bioengineered cells significantly decreased the infarct area and improved heart function, showing possible clinical relevance “It is widely acknowledged ...

Researchers have trained an artificial intelligence model to extract warning signs of advanced heart failure from routine ...

University of Alabama at Birmingham researchers, led by Jianyi “Jay” Zhang, M.D., Ph.D., and Lei Ye, M.D., Ph.D., generated the human leukocyte antigen-knockout and cyclin D2-overexpressing hiPSCs, ...