During cell division, intricate cellular machinery separates duplicated DNA into daughter cells. Unexpectedly, the assembly of this crucial apparatus seems to rely on components other than proteins ...

The small guanosine triphosphatase Ran loaded with GTP (RanGTP) can stimulate assembly of the type V intermediate filament protein lamin B into a membranous lamin B spindle matrix, which is required ...

Robert Blackwell, Christopher Edelmaier, Oliver Sweezy-Schindler, Adam Lamson, Zachary Gergely, Eileen O’Toole, Ammon Crapo, Loren Hough, J. Richard McIntosh ...

近日，四川大学林宏辉/邓星光团队在Science Advances发表了题为Arabidopsis KNL1 Recruits Type One Protein Phosphatase to Kinetochores to Silence the ...

Figure 1: A light micrograph of a large oocyte in an ovary. RIKEN researchers have found that MPS1 promotes timely spindle bipolarization when oocytes in mice undergo ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

Mechanistic model for MTOC maturation in GV oocytes. The MTOC (grey) activates near the oocyte cortex, which requires recruitment of CKAP5 and TACC3. After activation, MTOC migrates to the nuclear ...

Every biology class learns about mitosis, which involves copying each of a cell's DNA-containing chromosomes, then separating them into two newly created cells. The act of chromosome separation is ...

Modern CNC machine tools work under increasingly diverse cutting conditions. They must handle workpieces of various sizes and materials, and produce good surface finishes while operating at ever ...