Glutamate receptors, including AMPA and NMDA subtypes, are pivotal mediators of excitatory transmission and plasticity across the mammalian central nervous system. Their regulation, which involves ...

Can caffeine save your social life? New research shows how caffeine restores social memory impaired by sleep deprivation by targeting the hippocampal CA2 region. Learn about the molecular mechanisms ...

Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have demonstrated that ...

A study mapped genes linked to schizophrenia and uncovered a mechanism that disrupts synaptic plasticity in affected individuals. The researchers showed the role of three proteins in mediating the ...

Sleep loss selectively disrupts memory-related brain circuits and behavior, while caffeine restores synaptic plasticity and ...

Cognitive tasks, such as learning and memory, require rapid changes to proteins at synapses, such as protein synthesis, degradation, and trafficking. How protein post-translational modifications ...

The choice of rodent strain for neuroscientific research is often considered a secondary factor when selecting rat or mouse models for functional studies of ...

Alzheimer's disease (AD) is a debilitating neurodegenerative condition that affects a significant proportion of older people worldwide. Synapses are points of communication between neural cells that ...

Neurons are important, but they are not everything. Indeed, it is "cartilage," in the form of clusters of extracellular matrix molecules called chondroitin sulfates, located in the outside nerve cells ...

New research on the hippocampus, a brain area essential for memory, suggests that new rules of synaptic plasticity best explain how brain activity continually reshapes the way memories are recorded in ...