Charles W.M. Roberts, MD, PhD, executive vice president and Comprehensive Cancer Center director at St. Jude Children's ...

Kazia Therapeutics Limited (Nasdaq: KZIA), a clinical-stage oncology company advancing therapies to reprogram cancer biology and overcome treatment resistance, announces the in-licensing of a first-in ...

Super-enhancers (SEs) are large clusters of transcriptional regulatory elements that drive oncogene expression, maintain malignancy, and create ...

Super-enhancers (SEs) are large clusters of transcriptional regulatory elements that drive oncogene expression, maintain malignancy, and create “transcriptional addiction” in cancer. They function via ...

Why is the timing of trauma so important? New research shows that estrogen levels in the hippocampus at the moment of stress ...

Anti-cancer drugs often fail, but a new discovery about how two key proteins interact with DNA is changing that, serving as a ...

Every cell in your body faces the same engineering puzzle: how to cram roughly two meters of DNA into a nucleus just a few ...

Two BET proteins play distinct roles in gene activation, explaining why BET-targeting therapies have limited responses and ...

Using rapid protein degradation, chemogenomics, and super‑resolution microscopy in mouse embryonic stem cells, the team dissected the distinct contributions of BRD2 and BRD4 to transcription.

Cancer drugs known as BET inhibitors once looked like a breakthrough, but in real patients they’ve often fallen short. New ...

DNA inside the nucleus is not packed as a rigid regular fiber-linker histone H1 dynamically binds and loosely "glues" ...

DNA inside the nucleus is not packed as a rigid regular fiber—linker histone H1 dynamically binds and loosely "glues" ...